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    You are at:Home»Sports Trends»2025 NFL Odds Week 16: Lines, Spreads for all 16 Games
    Sports Trends

    2025 NFL Odds Week 16: Lines, Spreads for all 16 Games

    Ironside Sports MediaBy Ironside Sports MediaDecember 15, 2025No Comments2 Mins Read
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    NFL Week 16 kicks off on Thursday, as the Falcons host the Buccaneers.

    Here are the lines for every Week 16 matchup at DraftKings Sportsbook as of Dec. 14.

    This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

    THURSDAY, DEC. 18

    RAMS @ SEAHAWKS

    Spread: Rams -1.5
    Moneyline: Rams -112, Seahawks -108
    O/U: 45.5

    SATURDAY, DEC. 20

    EAGLES @ COMMANDERS

    Spread: Eagles -6
    Moneyline: Eagles -278, Commanders +225
    O/U: 45.5

    PACKERS @ BEARS

    Spread: Packers -2.5
    Moneyline: Packers -135, Bears +114
    O/U: 46.5

    SUNDAY, DEC. 21

    BILLS @ BROWNS

    Spread: Bills -10
    Moneyline: Bills -575, Browns +425
    O/U: 42.5

    CHARGERS @ COWBOYS

    Spread: Cowboys -1.5
    Moneyline: Cowboys -125, Chargers +105
    O/U: 49.5

    CHIEFS @ TITANS

    Spread: Chiefs -4.5
    Moneyline: Chiefs -238, Titans +195
    O/U: 37.5

    BENGALS @ DOLPHINS

    Spread: Dolphins -1.5
    Moneyline: Dolphins -118, Bengals -102
    O/U: 50.5

    JETS @ SAINTS

    Spread: Saints -4.5
    Moneyline: Saints -218, Jets +180
    O/U: 40.5

    VIKINGS @ GIANTS

    Spread: Vikings -1.5
    Moneyline: Vikings -125, Giants +105
    O/U: 43.5

    BUCCANEERS @ PANTHERS

    Spread: Buccaneers -1.5
    Moneyline: Buccaneers -125, Panthers +105
    O/U: 45.5

    JAGUARS @ BRONCOS

    Spread: Broncos -2.5
    Moneyline: Broncos -155, Jaguars +130
    O/U: 44.5

    FALCONS @ CARDINALS

    Spread: Falcons -1.5
    Moneyline: Falcons -130, Cardinals +110
    O/U: 46.5

    STEELERS @ LIONS

    Spread: Lions -7
    Moneyline: Lions -345, Steelers +275
    O/U: 49.5

    RAIDERS @ TEXANS

    Spread: Texans -14.5
    Moneyline: Texans -1450, Raiders +850
    O/U: 37.5

    PATRIOTS @ RAVENS

    Spread: Ravens -2.5
    Moneyline: Ravens -142, Patriots +120
    O/U: 48.5

    MONDAY, DEC. 22

    49ERS @ COLTS

    Spread: 49ers -4.5
    Moneyline: 49ers -258, Colts +210
    O/U: 45.5

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