The Arizona Cardinals will host the Seattle Seahawks on Sunday in a Week 2 NFL showdown on FOX.
The defending Super Bowl champions opened their 2026 campaign with a 13-10 win over the New England Patriots. However, quarterback Sam Darnold exited in the first quarter and will miss Seattle’s Week 2 matchup. Drew Lock will start in his absence.
After falling behind 10-0, the Seahawks scored 13 unanswered points to begin 2026 the same way they ended 2025: with a win over the Patriots. Seattle’s defense picked off Drake Maye three times and held an explosive New England offense to just 10 points.
The Seahawks allowed an NFL-low 17.2 points per game last season, and their defense already appears poised for another dominant year.
Meanwhile, the Cardinals pulled off the biggest upset of Week 1, beating the Chargers on the road as 9.5-point underdogs. An Arizona defense that ranked near the bottom of several categories last season held Los Angeles to 14 points, 209 passing yards and 3.9 yards per carry while recording three sacks and generating consistent pressure throughout the game.
Jacoby Brissett also impressed, completing 27 of 37 passes for 277 yards and a touchdown.
Can Arizona pull off two straight upsets to begin the season?
Let’s take a look at the odds for Seahawks vs. Cardinals at FanDuel Sportsbook as of Sept. 20.
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Moneyline
- Seahawks: -200 (bet $10 to win $15 total)
- Cardinals: +168 (bet $10 to win $26.80 total)
Unfold
- Seahawks -3.5: -110 (bet $10 to win $19.09 total)
- Cardinals +3.5: -110 (bet $10 to win $19.09 total)
Over/Beneath
- Over 41.5: -110 (bet $10 to win $19.09 total)
- Under 41.5: -110 (bet $10 to win $19.09 total)
Seahawks @ Cardinals Prediction, Choose
From FOX Sports activities Analysis:
Drew Lock impressed in reduction in Week 1, finishing 16 of twenty-two passes for 187 yards and a landing. Nonetheless, the Patriots weren’t anticipating to face him. However the Cardinals will probably be. Arizona has now had a full week to organize for Lock and construct its defensive recreation plan round stopping him.
It may be an overreaction to at least one recreation, however the Cardinals seemed like a strong workforce able to exceeding expectations of their first season below head coach Mike LaFleur. Their protection seemed fully remodeled from a yr in the past, and Arizona now has a authentic likelihood to go 2-0, particularly with a backup quarterback coming to city.
The Cardinals additionally don’t have any scarcity of offensive weapons as Trey McBride, Jeremiyah Love, Marvin Harrison Jr. and firm will look to place up large numbers as soon as once more.
Take Arizona to maintain this recreation shut and canopy the three.5-point unfold.
The Choose: Cardinals +3.5
Methods to Watch Seahawks vs. Cardinals
- Date: Sunday, Sept. 20. 2026
- Time: 4:25 p.m. ET
- TV: FOX
- Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
- Location: State Farm Stadium, Glendale, AZ
