NFL Week 8 kicks off Thursday night, as the Chargers host the Vikings.
Here are the lines for every Week 8 matchup at DraftKings Sportsbook as of Oct. 21.
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2025 NFL Week 8 Odds
THURSDAY, OCT. 23
Spread: Chargers -3.5
Moneyline: Chargers -170, Vikings +142
Over/Under: 44.5
SUNDAY, OCT. 26
Spread: Bills -7.5
Monyeline: Bills -360, Panthers +285
Over/Under: 45.5
Spread: Eagles -7
Moneyline: Eagles -355, Giants +280
Over/Under: 43.5
Spread: Patriots -7
Moneyline: Patriots -345, Browns +275
Over/Under: 40.5
Spread: Ravens -6.5
Moneyline: Ravens -325, Bears +260
Over/Under: 49.5
Spread: Bengals -7
Moneyline: Bengals -340, Jets +270
Over/Under: 44.5
Spread: Falcons -7
Moneyline: Falcons -360, Dolphins +285
Over/Under: 44.5
Spread: 49ers -1.5
Moneyline: Texans -102, 49ers -118
Over/Under: 40.5
Spread: Buccaneers -4.5
Moneyline: Buccaneers -230, Saints +190
Over/Under: 46.5
Spread: Broncos -3
Moneyline: Broncos -175, Cowboys +145
Over/Under: 50.5
Spread: Colts -14
Moneyline: Colts -1050, Titans +675
Over/Under: 47.5
Spread: Packers -3
Moneyline: Packers -185, Steelers +154
Over/Under: 44.5
MONDAY, OCT. 27
Spread: Chiefs -10
Moneyline: Chiefs -625, Commanders +455
Over/Under: 47.5
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