NFL Week 6 kicks off Thursday night, as the Giants host the Eagles.
Here are the lines for every Week 6 matchup at DraftKings Sportsbook as of Oct. 11.
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(All times ET)
2025 NFL Week 6 Odds
THURSDAY, OCT. 9
Spread: Eagles -7 (Giants cover)
Over/Under: 40.5 (Over hits)
SUNDAY, OCT. 12
Spread: Broncos -7.5
Moneyline: Broncos -410, Jets +320
Over/Under: 43.5
Spread: Colts -7
Moneyline: Colts -340, Cardinals +270
Over/Under: 47.5
Spread: Cowboys -3
Moneyline: Cowboys -175, Panthers +145
Over/Under: 49.5
Spread: Rams -7
Moneyline: Rams -360, Ravens +285
Over/Under: 44.5
Spread: Chargers -4.5
Moneyline: Chargers -218, Dolphins +180
Over/Under: 43.5
Spread: Patriots -3.5
Moneyline: Patriots -198, Saints +164
Over/Under: 45.5
Spread: Steelers -5.5
Moneyline: Steelers -270, Browns +220
Over/Under: 37.5
Spread: Seahawks -1.5
Moneyline: Jaguars -110, Seahawks -110
Over/Under: 47.5
Spread: Raiders -4.5
Moneyline: Raiders -218, Titans +180
Over/Under: 41.5
Spread: Packers -14.5
Moneyline: Packers -1050, Bengals +675
Over/Under: 44.5
Spread: Buccaneers -3.5
Moneyline: Buccaneers -185, 49ers +154
Over/Under: 47.5
Spread: Chiefs -2.5
Moneyline: Chiefs -130, Lions +110
Over/Under: 52.5
MONDAY, OCT. 13
Spread: Bills -4.5
Moneyline: Bills -225, Falcons +185
Over/Under: 49.5
Spread: Commanders -4.5
Moneyline: Commanders -225, Bears +185
Over/Under: 49.5
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