2025 NFL odds Week 1: Lines, spreads for all 16 games

The NFL season is sort of upon us. 

The 2025-26 NFL schedule has formally been launched, which means it’s time to begin inserting wagers.

The Tremendous-Bowl-champion Philadelphia Eagles will kick off the 2025 season by internet hosting their NFC East rivals, the Dallas Cowboys, on Sept. 4.

With a loaded Week 1 slate, let’s take a look at the traces for every recreation at DraftKings Sportsbook as of Could 15. 

(All occasions ET)

2024 NFL Week 1 Odds and Predictions

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

Level unfold: Eagles -7 (Eagles favored to win by 7 factors or extra, in any other case Cowboys cowl)
Moneyline: Eagles -310 favorites to win (wager $10 to win $13.23 complete); Cowboys +250 underdogs to win (wager $10 to win $35 complete)
Whole scoring Over/Underneath: 46.5 factors scored by each groups mixed

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Level unfold: Chiefs -3 (Chiefs favored to win by 3 factors or extra, in any other case Chargers cowl)
Moneyline: Chiefs -155 favorites to win (wager $10 to win $16.45 complete); Chargers +130 underdogs to win (wager $10 to win $23 complete)
Whole Over/Underneath: 44.5 factors scored by each groups mixed

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Level unfold: Patriots -3.5 (Patriots favored to win by 4 factors or extra, in any other case Raiders cowl)
Moneyline: Patriots -166 favorites to win (wager $10 to win $16.02 complete); Raiders +140 underdogs to win (wager $10 to win $24 complete)
Whole Over/Underneath: 43.5 factors scored by each groups mixed

STEELERS @ JETS (1 p.m., CBS)

Level unfold: Steelers -2.5 (Steelers favored to win by 3 factors or extra, in any other case Jets cowl)
Moneyline: Steelers -142 favorites to win (wager $10 to win $17.04 complete); Jets +120 underdogs to win (wager $10 to win $22 complete)
Whole Over/Underneath: 39.5 factors scored by each groups mixed

DOLPHINS @ COLTS (1 p.m., CBS)

Level unfold: Colts -1.5 (Colts favored to win by 2 factors or extra, in any other case Dolphins cowl)
Moneyline: Colts -120 favorites to win (wager $10 to win $18.33 complete); Dolphins +100 underdogs to win (wager $10 to win $20 complete)
Whole Over/Underneath: 45.5 factors scored by each groups mixed

CARDINALS @ SAINTS (1 p.m., CBS)

Level unfold: Cardinals -3.5 (Cardinals favored to win by 4 factors or extra, in any other case Saints cowl)
Moneyline: Cardinals -192 favorites to win (wager $10 to win $15.21 complete); Saints +160 underdogs to win (wager $10 to win $26 complete)
Whole Over/Underneath: 43.5 factors scored by each groups mixed

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)

Level unfold: Commanders -7.5 (Commanders favored to win by 8 factors or extra, in any other case Giants cowl)
Moneyline: Commanders -340 favorites to win (wager $10 to win $12.94 complete); Giants +270 underdogs to win (wager $10 to win $37 complete)
Whole Over/Underneath: 45.5 factors scored by each groups mixed

PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports app)

Level unfold: Jaguars -3.5 (Jaguars favored to win by 4 factors or extra, in any other case Panthers cowl)
Moneyline: Jaguars -166 favorites to win (wager $10 to win $16.02 complete) Panthers +140 underdogs to win (wager $10 to win $24 complete)
Whole Over/Underneath: 45.5 factors scored by each groups mixed

BENGALS @ BROWNS (1 p.m., FOX and FOX Sports app)

Level unfold: Bengals -4.5 (Bengals favored to win by 5 factors or extra, in any other case Browns cowl)
Moneyline: Bengals -218 favorites to win (wager $10 to win $14.59 complete); Browns +180 underdogs to win (wager $10 to win $28 complete)
Whole Over/Underneath: 44.5 factors scored by each groups mixed

BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports app)

Level unfold: Buccaneers -2.5 (Buccaneers favored to win by 3 factors or extra, in any other case Falcons cowl)
Moneyline: Buccaneers -142 favorites to win (wager $10 to win $17.04 complete); Falcons +120 underdogs to win (wager $10 to win $22 complete)
Whole Over/Underneath: 47.5 factors scored by each groups mixed

TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports app)

Level unfold: Broncos -7.5 (Broncos favored to win by 8 factors or extra, in any other case Titans cowl)
Moneyline: Broncos -375 favorites to win (wager $10 to win $12.67 complete); Titans +295 underdogs to win (wager $10 to win $39.50 complete)
Whole Over/Underneath: 43.5 factors scored by each groups mixed

49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports app)

Level unfold: 49ers -1.5 (49ers favored to win by 2 factors or extra, in any other case Seahawks cowl)
Moneyline: 49ers -120 favorites to win (wager $10 to win $18.33 complete); Seahawks +100 underdogs to win (wager $10 to win $20 complete)
Whole Over/Underneath: 45.5 factors scored by each groups mixed

LIONS @ PACKERS (4:25 p.m., CBS)

Level unfold: Packers -1.5 (Packers favored to win by 2 factors or extra, in any other case Lions cowl)
Moneyline: Packers -118 favorites to win (wager $10 to win $18.47 complete); Lions -102 underdogs to win (wager $10 to win $19.80 complete)
Whole Over/Underneath: 48.5 factors scored by each groups mixed

TEXANS @ RAMS (4:25 p.m., CBS)

Level unfold: Rams -3.5 (Rams favored to win by 4 factors or extra, in any other case Texans cowl)
Moneyline: Rams -175 favorites to win (wager $10 to win $15.71 complete); Texans +145 underdogs to win (wager $10 to win $24.50 complete)
Whole Over/Underneath: 44.5 factors scored by each groups mixed

RAVENS @ BILLS (8:20 p.m., NBC)

Level unfold: Payments -1.5 (Payments favored to win by 2 factors or extra, in any other case Ravens cowl)
Moneyline: Payments -122 favorites to win (wager $10 to win $18.20 complete); Ravens +102 underdogs to win (wager $10 to win $20.20 complete)
Whole Over/Underneath: 51.5 factors scored by each groups mixed 

MONDAY, SEPT. 8

VIKINGS @ BEARS (8:15 p.m., ESPN)

Level unfold: Bears -1.5 (Bears favored to win by 2 factors or extra, in any other case Vikings cowl)
Moneyline: Bears -122 favorites to win (wager $10 to win $18.20 complete); Vikings +102 underdogs to win (wager $10 to win $20.20 complete)
Whole Over/Underneath: 45.5 factors scored by each groups mixed

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